翻訳と辞書 Words near each other ・ Carboxymethyloxysuccinate lyase ・ Carboxynorspermidine decarboxylase ・ Carboxynorspermidine synthase ・ Carboxypenicillin ・ Carboxypeptidase ・ Carboxypeptidase A ・ Carboxypeptidase A inhibitor ・ Carboxypeptidase A1 ・ Carboxypeptidase A2 ・ Carboxypeptidase A6 ・ Carboxypeptidase B ・ Carboxypeptidase B2 ・ Carboxypeptidase C ・ Carboxypeptidase D ・ Carboxypeptidase D (disambiguation) ・ Carboxypeptidase E ・ Carboxypeptidase G ・ Carboxypeptidase M ・ Carboxypeptidase P ・ Carboxypeptidase T ・ Carboxypeptidase Taq ・ Carboxypeptidase U ・ Carboxysome ・ Carboxytherapy ・ Carboxyvinyl-carboxyphosphonate phosphorylmutase ・ Carboy ・ Carbrain, Cumbernauld ・ Carbridge ・ Carbrini Sportswear ・ Carbromal Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Carboxypeptidase E ： ウィキペディア英語版 Carboxypeptidase E Carboxypeptidase E (CPE), also known as carboxypeptidase H (CPH) and convertase, is an enzyme that in humans is encoded by the ''CPE'' gene〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1363 )〕 This enzyme catalyzes the release of C-terminal arginine or lysine residues from polypeptides. CPE is involved in the biosynthesis of most neuropeptides and peptide hormones. The production of neuropeptides and peptide hormones typically requires two sets of enzymes that cleave the peptide precursors, which are small proteins. First, proprotein convertases cut the precursor at specific sites to generate intermediates containing C-terminal basic residues (lysine and/or arginine). These intermediates are then cleaved by CPE to remove the basic residues. For some peptides, additional processing steps, such as C-terminal amidation, are subsequently required to generate the bioactive peptide, although for many peptides the action of the proprotein convertases and CPE is sufficient to produce the bioactive peptide. == Tissue distribution == Carboxypeptidase E is found in brain and throughout the neuroendocrine system, including the endocrine pancreas, pituitary, and adrenal gland chromaffin cells. Within cells, carboxypeptidase E is present in the secretory granules along with its peptide substrates and products. Carboxypeptidase E is a glycoprotein that exists in both membrane-associated and soluble forms. The membrane-binding is due to an amphiphilic α-helix within the C-terminal region of the protein. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Carboxypeptidase E」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.